We present the case of a patient with endometrial adenocarcinoma associated with acanthosis nigricans and tripe palms which we have been following for the past 7 years.

Endometrial adenocarcinoma associated with malignant acanthosis nigricans without tripe palms has been cited in three case reports, and endometrial adenocarcinoma associated with tripe palms without malignant acanthosis nigricans has been cited in one case report. Cette revue de la littérature a pour but de mieux informer les praticiens oncologues de l’existence et des spécificités de ces syndromes rares.īackground:In the world literature, uterine carcinoma associated with paraneoplastic malignant acanthosis nigricans and tripe palms has been mentioned in two review articles. Nous avons réalisé une revue systématique de la littérature des syndromes paranéoplasiques publiés durant les trois dernières décennies, ayant été décrits chez les patients dont l’origine de la tumeur primitive n’a pas été retrouvée. Ces syndromes peuvent entraîner des dysfonctions de tous les organes et systèmes vitaux chez les patients. Il n’y a notamment pas d’association connue entre syndrome paranéoplasique et type histologique du CPU. Les syndromes paranéoplasiques associés au cancer de primitif inconnu (CPU) sont peu connus en raison de leur rareté. Les syndromes paranéoplasiques sont des manifestations cliniques et biologiques qui résultent de dégâts tissulaires survenant à distance de la tumeur primitive. One additional goal of this article is to make practicing oncologists aware of the coexistence of paraneoplastic syndromes in patients with CUP. In this article, we review the available literature of CUP patients presenting paraneoplastic syndromes by trying to collect all available published cases during the last three decades. However, they can also herald earlier the occurrence of CUP in patients with asymptomatic tumors. In some instances, paraneoplastic syndromes can become the major clinical problems determining survival. To our knowledge, the association between the histological CUP type and the paraneoplastic syndrome has never been assessed. These syndromes can impair various organ functions and include endocrine, neurologic, dermatologic, rheumatologic, hematologic and several other system alterations.

Paraneoplastic syndromes associated with cancer of unknown primary (CUP) are not well recognized as they are rarely reported. Paraneoplastic syndromes are signs or symptoms that result from tissue damage at locations remote from tumour sites.

The unknown by jw lynne